Relevant Publications

  • Corbellari R, Tomasi M, Benedet M, Begaj R, Gagliardi A, Zanella I, Tamburini S, Caproni E, Shaba E, Di Lascio G, Facchini V, Baraldi C, Gambini G, Berti A, Lunardi A, Bini L, Grandi G and Grandi A (2026) Cytokine-bearing Bacterial Outer Membrane Vesicles with Empowered Efficacy in Intratumoral Immunotherapy. (Under review)
  • Tomasi M, Croia L, Zanella I, Gagliardi A, Boscato Sopetto G, Benedet M, Di Lascio G, Gambini G, Berti A, Corbellari R, Grandi G and Grandi A (2025) Investigation on antigen-specific T-cell responses induced by outer membrane vesicles from Escherichia coli Δ60 strain. Front. Immunol. 16:1633961. doi: 10.3389/fimmu.2025.1633961
  • Croia L, Boscato Sopetto G, Zanella I, Caproni E, Gagliardi A, Tamburini S, König E, Benedet M, Di Lascio G, Corbellari R, Grandi A, Tomasi M, Grandi G (2023) Immunogenicity of Escherichia coli Outer Membrane Vesicles: Elucidation of Humoral Responses against OMV-Associated Antigens. Membranes, 13(11), 882. https://doi.org/10.3390/membranes13110882
  • Tamburini S, Zhang Y, Gagliardi A, Di Lascio G, Caproni E, Benedet M, Tomasi M, Corbellari R, Zanella I, Croia L, Grandi G, Müller M, Grandi A (2023) Bacterial Outer Membrane Vesicles as a Platform for the Development of a Broadly Protective Human Papillomavirus Vaccine Based on the Minor Capsid Protein L2. Vaccines, 11(10), 1582. https://doi.org/10.3390/vaccines11101582
  • Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Di Lascio G, Tamburini S, Caproni E, Croia L, Ravà M, Fumagalli V, Di Lucia P, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil P, Cherepanov P, Bolognesi M, Pizzato M, Grandi, G. (2023) Immunogenicity and Pre-Clinical Efficacy of an OMV-Based SARS-CoV-2 Vaccine. Vaccines, 11(10), 1546. https://doi.org/10.3390/vaccines11101546
  • Caproni E, Corbellari R, Tomasi M, Isaac S, Tamburini S, Zanella I, Grigolato M, Gagliardi A, Benedet M, Baraldi C, Croia L, Di Lascio G, Berti A, Valensin S, Bellini E, Parri M, Grandi A, Grandi G (2023) Anti-Tumor Efficacy of In Situ Vaccination Using Bacterial Outer Membrane Vesicles. Cancers, 15(13), 3328. https://doi.org/10.3390/cancers15133328
  • Tomasi M, Caproni E, Benedet M, Zanella I, Giorgetta S, Dalsass M, König E, Gagliardi A, Fantappiè L, Berti A, Tamburini S, Croia L, Di Lascio G, Bellini E, Valensin S, Licata G, Sebastiani G, Dotta F, Armanini F, Cumbo F, Asnicar F, Blanco-Míguez A, Ruggiero E, Segata N, Grandi G and Grandi A (2022) Outer Membrane Vesicles From The Gut Microbiome Contribute to Tumor Immunity by Eliciting Cross-Reactive T Cells. Front. Oncol. 12:912639. doi: 10.3389/fonc.2022.912639
  • Tomasi M, Dalsass M, Beghini F, Zanella I, Caproni E, Fantappiè L, Gagliardi A, Irene C, König E, Frattini L, Masetti G, Isaac S, Armanini F, Cumbo F, Blanco-Míguez A, Grandi A, Segata N and Grandi G (2021) Commensal Bifidobacterium Strains Enhance the Efficacy of Neo-Epitope Based Cancer Vaccines. Vaccines (Basel). 18;9(11):1356. doi: 10.3390/vaccines9111356
  • König E, Gagliardi A, Riedmiller I, Andretta C, Tomasi M, Irene C, Frattini L, Zanella I, Berti F, Grandi, Caproni E, Fantappiè L, Grandi G (2021) Multi-Antigen Outer Membrane Vesicle Engineering to Develop Polyvalent Vaccines: The Staphylococcus aureus Case. Front Immunol. 12:752168. doi: 10.3389/fimmu.2021.752168
  • Zanella I, König E, Tomasi M, Gagliardi A, Isaac S, Grigolato M, Frattini L, Zerbini F, Fantappiè L, Irene C, Caproni E, Corbellari R, Valensin S, Bini L, Ashhab Y, Grandi A, Grandi G (2021) Proteome-minimized Outer Membrane Vesicles from Escherichia coli as a vaccine platform for infectious diseases and cancer. J Extracellular Vesicles. 10(4):e12066. doi: 10.1002/jev2.12066
  • Carmela I, Fantappie L, Caproni E, Zerbini F, Anesi A, Tomasi M, Zanella I, Stupia S, Prete S, Valensin S, Koenig E, Frattini L, Gagliardi A, Isaac SJ, Grandi A, Guella G and Grandi G (2019) Vaccines based on Bacterial Outer membrane Vesicles engineered with lipidated heterologous antigens: the Staphylococcus aureus case. Proc. Natl. Acad. Sci. USA, 116, 21780-21788
  • Grandi A, Fantappiè L, Irene C, Valensin S, Tomasi M, Stupia S, Corbellari R, Caproni E, Zanella I, Isaac SJ, Ganfini L, Frattini L, König E, Gagliardi A, Tavarini S, Sammicheli C, Parri M, Grandi G (2018) Vaccination With a FAT1-Derived B Cell Epitope Combined With Tumor-Specific B and T Cell Epitopes Elicits Additive Protection in Cancer Mouse Models. Front Oncol. 8:481. doi: 10.3389/fonc.2018.00481
  • Grandi A, Tomasi M, Zanella I, Ganfini L, Caproni E, Fantappiè L, Irene C, Frattini L, Isaac SJ, König E, Zerbini F, Tavarini S, Sammicheli C, Giusti F, Ferlenghi I, Parri M, Grandi G (2017) Synergistic Protective Activity of Tumor-Specific Epitopes Engineered in Bacterial Outer Membrane Vesicles. Front Oncol. 7: 253. doi: 10.3389/fonc.2017.00253.
  • Fantappiè L, Irene C, De Santis M, Armini A, Gagliardi A, Tomasi M, Parri M, Cafardi V, Bonomi S, Ganfini L, Zerbini F, Zanella I, Carnemolla C, Bini L, Grandi A, Grandi G (2017) Some Gram-negative Lipoproteins Keep Their Surface Topology When Transplanted from One Species to Another and Deliver Foreign Polypeptides to the Bacterial Surface. Mol Cell Proteomics. 16:1348-1364. doi: 10.1074/mcp.M116.065094
  • Zerbini F, Zanella I, Fraccascia D, König E, Irene C, Frattini LF, Tomasi M, Fantappiè L, Ganfini L, Caproni E, Parri M, Grandi A, Grandi G (2017) Large scale validation of an efficient CRISPR/Cas-based multi gene editing protocol in Escherichia coli. Microb Cell Fact. 16: 68. doi: 10.1186/s12934-017-0681-1
  • Grandi A, Tomasi M, Grandi G (2016) Vaccinology: The art of putting together the right ingredients. Hum Vaccin Immunother. 12:1311-7. doi: 10.1080/21645515.2015.1123829.
  • Fantappiè L, de Santis M, Chiarot E, Carboni F, Bensi G, Jousson O, Margarit I, Grandi G (2014) Antibody-mediated immunity induced by engineered Escherichia coli OMVs carrying heterologous antigens in their lumen. J Extracell Vesicles. 3. doi: 10.3402/jev.v3.24015